Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study

Abstract To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 underwent whole-body spirometry as part KORA-FF4 cohort study. Lung semi-automatically using an in-house algorithm. Forced expiratory volume one second (FEV1), forced vital capacity (FVC), residual were measured. Cardiac parameters Cine-SSFP-sequence cvi42, while left ventricle (LV) time-volume-curves evaluated pyHeart. Linear regression analyses assessed relationships PFT MRI-based volumes. Mean age was 56.3 ± 9.2 years (57% males). LV right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, peak ejection- early/late diastolic filling rate associated FEV1, FVC, (excluding late end-systolic/stroke RV end-diastolic/end-systolic volume). In contrast, end-diastolic (ß = − 0.14, p 0.01), early 0.11, 0.04), LV/RV 0.01; ß 0.01) inversely volume. Subclinical impairment reduced decreased increasing contrasting results PFT.